Dallas Center-Grimes posted its second shutout in three weeks with a 28-0 blanking at Knoxville on Sept. 27.
Chaz Chambers ran for 198 yards and two touchdowns, the longest an 82-yard score.
"I think we saw a glimpse of the big-play capabilities Chaz has," coach Scott Heitland said.
Andrew Kramer threw for 157 yards and threw two touchdown passes to Dakota Clausen, who caught five passes for 94 yards.
Jack Kelly paced the defense with nine tackles. Brevin Towsnell and Justin Gardner each added six.
The Mustangs won despite turning the ball over four times, including three interceptions.
"We were able to play through those mistakes and come out with a win," Heitland said. "We won’t be able to turn the ball over four times and win Friday night."
With the win, DC-G improved to 4-1 on the season and surpassed last season’s win total. The Mustangs are 2-0 in Class 3A District 4 play, one of two undefeated teams, along with Boone. The Toreadors are 3-0 in district play and 5-0 overall.
The Mustangs return home to host Newton in a homecoming battle on Friday, while Boone faces a non-district trip to Iowa Falls-Alden. The Cardinals are 2-3 overall and 1-2 in district play after a 60-35 loss to Grinnell last week.